%0 Journal Article
%T Heterogeneity of BRAF, NRAS, and TERT Promoter Mutational Status in Multiple Melanomas and Association with MC1R Genotype: Findings from Molecular and Immunohistochemical Analysis
%A Ambra Antonini
%A Claudia Martorelli
%A Cristina Pellegrini
%A Gianluca Cipolloni
%A Ketty Peris
%A Laura Del Regno
%A Lucia Di Nardo
%A Maria Concetta Fargnoli
%A Maria Giovanna Maturo
%A Marina De Padova
%A Pietro Leocata
%A Sara Strafella
%A Tamara Micantonio
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2017.10.002
%X Data on somatic heterogeneity and germline¨Csomatic interaction in multiple primary
melanoma (MPM) patients are limited. We investigated the mutational status of BRAF,
NRAS, and TERT promoter genes in 97 melanomas of 44 MPM patients and compared molecular
and immunohistochemical findings. We further evaluated the association of somatic
alterations with the germline MC1R genotype. Mutations in BRAF gene were identified
in 41.2% (40/97) of melanomas, in NRAS in 2.1% (2/97), and in TERT promoter in 19.6%
(19/97).
%U https://jmd.amjpathol.org/article/S1525-1578(17)30387-2/fulltext