%0 Journal Article
%T Diagnostic Detection of Allelic Losses and Imbalances by Next-Generation Sequencing: 1p/19q Co-Deletion Analysis of Gliomas
%A Hendrikus J. Dubbink
%A Johan M. Kros
%A Martin J. van den Bent
%A Niels M.G. Krol
%A Peggy N. Atmodimedjo
%A Peter H.J. Riegman
%A Ronald van Marion
%A Winand N.M. Dinjens
%J The Journal of Molecular Diagnostics
%D 2016
%R 10.1016/j.jmoldx.2016.06.002
%X Cancer cells are genomically unstable and accumulate tumor type¨Cspecific molecular
aberrations, which may represent hallmarks for predicting prognosis and targets for
therapy. Co-deletion of chromosomes 1p and 19q marks gliomas with an oligodendroglioma
component and predicts a better prognosis and response to chemotherapy. In the current
study, we present a novel method to detect chromosome 1p/19q co-deletion or loss of
heterozygosity (LOH) in a diagnostic setting, based on single-nucleotide polymorphism
(SNP) analysis and next-generation sequencing (NGS).
%U https://jmd.amjpathol.org/article/S1525-1578(16)30090-3/fulltext