%0 Journal Article
%T Describing the Reportable Range Is Important for Reliable Treatment Decisions: A Multiple Laboratory Study for Molecular Tumor Profiling Using Next-Generation Sequencing
%A Cleo Keppens
%A Ed Schuuring
%A Elisabeth M.C. Dequeker
%A Jeroen Van Houdt
%A Karen Zwaenepoel
%A Lien Spans
%A Patrick Pauwels
%A V¨¦ronique Tack
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2018.06.006
%X Because interpretation of next-generation sequencing (NGS) data remains challenging,
optimization of the NGS process is needed to obtain correct sequencing results. Therefore,
extensive validation and continuous monitoring of the quality is essential. NGS performance
was compared with traditional detection methods and technical quality of nine NGS
technologies was assessed. First, nine formalin-fixed, paraffin-embedded patient samples
were analyzed by 114 laboratories by using different detection methods.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30624-4/fulltext