%0 Journal Article
%T Comprehensive Validation of Cytology Specimens for Next-Generation Sequencing and Clinical Practice Experience
%A Agnes Balla
%A Catherine E. Cottrell
%A Ken J. Hampel
%A Mukesh K. Sharma
%A Nikoletta Sidiropoulos
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2018.06.001
%X Biopsy specimens are subjected to an expanding portfolio of assays that regularly
include mutation profiling via next-generation sequencing (NGS). Specimens derived
via fine-needle aspiration, a common biopsy technique, are subjected to a variety
of cytopreparatory methods compared with surgical biopsies that are almost uniformly
processed as formalin-fixed, paraffin-embedded tissue. Therefore, the fine-needle
aspiration¨Cderived specimens most commonly accepted for molecular analysis are cell
blocks (CBs), because they are processed most similarly to surgical biopsy tissue.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30592-5/fulltext