%0 Journal Article
%T Development and Evaluation of a Pan-Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter Platform
%A Aly Karsan
%A Angela Goytain
%A Cheng-Han Lee
%A Kenneth T.E. Chang
%A Tony L. Ng
%A Torsten O. Nielsen
%A Tracy Tucker
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2017.09.007
%X The NanoString nCounter assay is a high-throughput hybridization technique using target-specific
probes that can be customized to test for numerous fusion transcripts in a single
assay using RNA from formalin-fixed, paraffin-embedded material. We designed a NanoString
assay targeting 174 unique fusion junctions in 25 sarcoma types. The study cohort
comprised 212 cases, 96 of which showed fusion gene expression by the NanoString assay,
including all 20 Ewing sarcomas, 11 synovial sarcomas, and 5 myxoid liposarcomas tested.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30314-8/fulltext