%0 Journal Article
%T Reference Size Matching, Whole-Genome Amplification, and Fluorescent Labeling as a Method for Chromosomal Microarray Analysis of Clinically Actionable Copy Number Alterations in Formalin-Fixed, Paraffin-Embedded Tumor Tissue
%A Aditi Khurana
%A Cynthe L. Sims
%A Jayne Scoggin
%A Mathew W. Moore
%A Philip D. Cotter
%A Samuel Koo
%A Shailin Govender
%A Shelly R. Gunn
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2018.01.004
%X Cancer genome copy number alterations (CNAs) assist clinicians in selecting targeted
therapeutics. Solid tumor CNAs are most commonly evaluated in formalin-fixed, paraffin-embedded
(FFPE) tissue by fluorescence in situ hybridization. Although fluorescence in situ
hybridization is a sensitive and specific assay for interrogating preselected genomic
regions, it provides no information about coexisting clinically significant copy number
changes. Chromosomal microarray analysis is an alternative DNA-based method for interrogating
genome-wide CNAs in solid tumors.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30253-2/fulltext