%0 Journal Article
%T Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens
%A Beatrice S. Knudsen
%A Elai Davicioni
%A Heesun Shin
%A Hyung L. Kim
%A Imelda Tenggara
%A Jeffry P. Simko
%A June M. Chan
%A Karen Chadwich
%A Lucia L.C. Lam
%A Matthew R. Cooperberg
%A Mohammed Alshalalfa
%A Neil Fleshner
%A Nicholas Erho
%A Peter R. Carroll
%A Theo Van Der Kwast
%J The Journal of Molecular Diagnostics
%D 2016
%R 10.1016/j.jmoldx.2015.12.006
%X Molecular and genomic analysis of microscopic quantities of tumor from formalin-fixed,
paraffin-embedded biopsy specimens has many unique challenges. Herein, we evaluated
the feasibility of obtaining transcriptome-wide RNA expression to measure prognostic
classifiers in diagnostic prostate needle core biopsy specimens. One-hundred fifty-eight
samples from diagnostic needle core biopsy specimens (BX) and radical prostatectomies
(RPs) were collected from 33 patients at three hospitals; each patient provided up
to six tumor and benign samples.
%U https://jmd.amjpathol.org/article/S1525-1578(16)00051-9/fulltext