%0 Journal Article
%T Varying Mutational Alterations in Multiple Primary Melanomas
%A Ann-Sophie Bohne
%A Axel Hauschild
%A Christoph R£¿cken
%A Friederike Egberts
%A Jochen Haag
%A J¨¹rgen Hedderich
%A Rainer Rompel
%A Sandra Kr¨¹ger
%J The Journal of Molecular Diagnostics
%D 2016
%R 10.1016/j.jmoldx.2015.07.010
%X In melanoma, the mitogen-activated protein (MAP) kinase pathway plays a crucial oncogenic
role. Recent studies identified additional genetic alterations, eg, TERT-promoter
mutations. Up to 8% of melanoma patients present with multiple primary melanomas (MPMs).
The pathogenesis is not fully understood, and data on the genetic diversity of MPMs
are limited. To identify putative diagnostic and therapeutic consequences, we assessed
the mutational status of the BRAF and NRAS genes and TERT promoter in patients with
MPMs.
%U https://jmd.amjpathol.org/article/S1525-1578(15)00229-9/fulltext