%0 Journal Article
%T Next-Generation Sequencing and Fluorescence in Situ Hybridization Have Comparable Performance Characteristics in the Analysis of Pancreaticobiliary Brushings for Malignancy
%A A. John Iafrate
%A Brenda Sweeney
%A Darrell Borger
%A David G. Forcione
%A Dora Dias-Santagata
%A Jonathan C. Dudley
%A Julie Batten
%A Kathy Vernovsky
%A Long P. Le
%A Martha B. Pitman
%A Ronald N. Arpin
%A Thomas McDonald
%A William R. Brugge
%A Zongli Zheng
%J The Journal of Molecular Diagnostics
%D 2016
%R 10.1016/j.jmoldx.2015.08.002
%X Cytological evaluation of pancreatic or biliary duct brushings is a specific, but
insensitive, test for malignancy. We compared adjunctive molecular testing with next-generation
sequencing (NGS) relative to fluorescence in situ hybridization (FISH) for detection
of high-risk neoplasia or malignancy. Bile duct brushings from 81 specimens were subjected
to cytological analysis, FISH using the UroVysion probe set, and targeted NGS. Specimens
were placed into negative/atypical (negative) or suspicious/positive (positive) categories
depending on cytology and negative or positive categories on the basis of FISH and
NGS results.
%U https://jmd.amjpathol.org/article/S1525-1578(15)00222-6/fulltext