%0 Journal Article
%T External Quality Assessment Identifies Training Needs to Determine the Neoplastic Cell Content for Biomarker Testing
%A Cleo Keppens
%A Elisabeth M.C. Dequeker
%A Gert De Hertogh
%A J. Han van Krieken
%A Kelly Dufraing
%A V¨¦ronique Tack
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2018.03.003
%X Neoplastic cell content determination is crucial for biomarker testing. It is known
that interobserver variation exists, but largescale data are missing about variation
in tumor delineation and cell content determination. Results were obtained from the
external quality assessment program for metastatic colorectal cancer from the European
Society of Pathology (N£¿=£¿5776 observations). The study included three parts: current
practices were surveyed, neoplastic cell content estimations and delineations were
retrieved from stained slides, and clinical reports were analyzed.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30617-7/fulltext