%0 Journal Article
%T Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma
%A Dale Bixby
%A Diane Roulston
%A Lina Shao
%A Sue Miller
%A Yunhong Wang
%J The Journal of Molecular Diagnostics
%D 2016
%R 10.1016/j.jmoldx.2016.03.004
%X Chromosomal abnormalities are important for the risk stratification of acute lymphoblastic
leukemia/lymphoma (ALL). However, approximately 30% of pediatric and 50% of adult
patients lack abnormalities with clinical relevance by traditional cytogenetic analysis.
We integrated cytogenetic, fluorescence in situ hybridization, and whole-genome single-nucleotide
polymorphism array results from 60 consecutive clinical ALL cases. By cytogenetic
and/or fluorescence in situ hybridization analyses, recurring abnormalities with clinical
relevance were observed in 33 B-cell ALL (B-ALL), including t(9;22), hyperdiploidy,
KMT2A translocation, ETV6-RUNX1, intrachromosomal amplification of chromosome 21,
near haploidy or low hypodiploidy, and t(8;22).
%U https://jmd.amjpathol.org/article/S1525-1578(16)30021-6/fulltext