%0 Journal Article
%T A Nanopore Sequencing¨CBased Assay for Rapid Detection of Gene Fusions
%A A. John Iafrate
%A Hayley Robinson
%A Jesse Lee
%A Long P. Le
%A Valentina Nardi
%A William R. Jeck
%J The Journal of Molecular Diagnostics
%D 2019
%R 10.1016/j.jmoldx.2018.08.003
%X Structural chromosomal rearrangements leading to gene fusions are strong driver mutations
in a variety of tumors. Identification of specific gene fusions can be essential for
distinguishing benign from malignant conditions and for recognizing specific subtypes
of neoplasms that can have different management and prognosis. Rapid identification
of gene fusions is particularly critical for patients with acute leukemia who cannot
wait more than a few days before initiating treatment and for whom treatment can be
dramatically different depending on the leukemia subtype.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30630-X/fulltext