%0 Journal Article
%T A Single-Tube, EuroClonality-Inspired, TRG Clonality Multiplex PCR Aids Management of Patients with Enteropathic Diseases, including from Formaldehyde-Fixed, Paraffin-Embedded Tissues
%A Am¨Ślie Trinquand
%A Bertrand Meresse
%A Christophe Cellier
%A Coralie Derrieux
%A David Sibon
%A Elizabeth Macintyre
%A Georgia Malamut
%A Julie Bruneau
%A Ludovic Lhermitte
%A Marion Alcantara
%A Nadine Cerf-Bensussan
%A Nicole Brousse
%A Olivier Hermine
%A Patrick Villarese
%A Thierry Molina
%A Virginie Verkarre
%J The Journal of Molecular Diagnostics
%D 2019
%R 10.1016/j.jmoldx.2018.08.006
%X Celiac disease is a chronic inflammation of the small intestine with villous atrophy
that can become refractory to a gluten-free diet. Two categories of refractory celiac
disease can be distinguished by the phenotype of intraepithelial lymphocytes and the
status of TRG genes. Their distinction is important because 30% to 50% of type II
but only 0% to 14% of type I evolve to an aggressive enteropathy-associated T-cell
lymphoma and therefore require intensive treatment. Currently, differential diagnosis
integrates immunohistochemistry, immunophenotyping, and TRG clonality analyses, but
each has limitations.
%U https://jmd.amjpathol.org/article/S1525-1578(18)30173-9/fulltext