%0 Journal Article
%T Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring ¦Â-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer's Disease
%A Andong Zhao
%A Jinsong Ren
%A Meng Li
%A Xiaogang Qu
%A Yijia Guan
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.18459
%X Development of sensitive detectors of A¦Â aggregates and effective inhibitors of A¦Â aggregation are of diagnostic importance and therapeutic implications for Alzheimer's disease (AD) treatment. Herein, a novel strategy has been presented by self-assembly of peptide conjugated Au nanorods (AuP) as multifunctional A¦Â fibrillization detectors and inhibitors. Our design combines the unique high NIR absorption property of AuNRs with two known A¦Â inhibitors, A¦Â15-20 and polyoxometalates (POMs). The synthesized AuP can effectively inhibit A¦Â aggregation and dissociate amyloid deposits with NIR irradiation both in buffer and in mice cerebrospinal fluid (CSF), and protect cells from A¦Â-related toxicity upon NIR irradiation. In addition, with the shape and size-dependent optical properties, the nanorods can also act as effective diagnostic probes to sensitively detect the A¦Â aggregates. This is the first report to integrate 3 segments, an A¦Â-targeting element, a reporter and inhibitors, in one drug delivery system for AD treatment.
%K Polyoxometalates
%K Au nanorod
%K Photothermal treatment
%K A¦Â inhibitors
%K A¦Â detectors
%K Alzheimer's Disease.
%U http://www.thno.org/v07p2996.htm