%0 Journal Article
%T pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression
%A Dongmei Cun
%A Haijun Yu
%A Jieying Yin
%A Qi Yin
%A Tianqun Lang
%A Yan Huang
%A Yaping Li
%A Zhong Zheng
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.21516
%X The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX and a siRNA, siAkt, directed at silencing the Akt expression.
%U http://www.thno.org/v07p4204.htm