%0 Journal Article
%T Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice
%A Chao Li
%A Dong Weng
%A Fangwei Liu
%A Jie Chen
%A Sitong Du
%A Siyi Li
%A Ying Chen
%A Yiping Lu
%A Yiting Zhang
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.20270
%X Inhalation of crystalline silica particles leads to pulmonary fibrosis, eventually resulting in respiratory failure and death. There are few effective drugs that can delay the progression of this disease; thus, patients with silicosis are usually only offered supportive care. Dioscin, a steroidal saponin, exhibits many biological activities and health benefits including its protective effects against hepatic fibrosis. However, the effect of dioscin on silicosis is unknown.
%K Crystalline silica
%K Pulmonary fibrosis
%K Dioscin
%K Immune response
%K Fibrocytes
%K Epithelial cells
%K Natural products therapy.
%U http://www.thno.org/v07p4255.htm