%0 Journal Article
%T Pro-Inflammatory CXCR3 Impairs Mitochondrial Function in Experimental Non-Alcoholic Steatohepatitis
%A Eagle SH Chu
%A Jinghua Du
%A Jun Yu
%A Juqiang Han
%A Kwan Man
%A Xiang Zhang
%A Yanquan Zhang
%A Yuemin Nan
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.21400
%X Mitochondrial dysfunction plays a crucial role in the development of non-alcoholic steatohepatitis (NASH). However, the regulator of mitochondrial dysfunction in the pathogenesis of NASH is still largely unclear. CXCR3 is an essential pro-inflammatory factor in chronic liver diseases. We explored the significance of CXCR3 in regulating mitochondrial function during NASH development in animal models and cultured hepatocytes.
%K CXCR3
%K non-alcoholic fatty liver diseases
%K mitochondria
%K apoptosis.
%U http://www.thno.org/v07p4192.htm