%0 Journal Article
%T Multimodal Assessment of Mesenchymal Stem Cell Therapy for Diabetic Vascular Complications
%A Christian J. Konopka
%A Hannah Bouvin
%A Heather D. Huntsman
%A Iwona T. Dobrucki
%A Jamila Hedhli
%A John A. Cole
%A Kristopher A. Kilian
%A Lawrence W. Dobrucki
%A Marni D. Boppart
%A Sarah Schuh
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.19547
%X Peripheral arterial disease (PAD) is a debilitating complication of diabetes mellitus (DM) that leads to thousands of injuries, amputations, and deaths each year. The use of mesenchymal stem cells (MSCs) as a regenerative therapy holds the promise of regrowing injured vasculature, helping DM patients live healthier and longer lives. We report the use of muscle-derived MSCs to treat surgically-induced hindlimb ischemia in a mouse model of type 1 diabetes (DM-1). We serially evaluate several facets of the recovery process, including ¦ÁV¦Â3-integrin expression (a marker of angiogenesis), blood perfusion, and muscle function. We also perform microarray transcriptomics experiments to characterize the gene expression states of the MSC-treated is- chemic tissues, and compare the results with those of non-ischemic tissues, as well as ischemic tissues from a saline-treated control group.
%K Angiogenesis
%K PET-CT
%K Dimeric-cRGD
%K Multimodal imaging
%K Peripheral arterial disease (PAD)
%K Diabetes
%K Muscle-derived mesenchymal stem cells (mMSCs).
%U http://www.thno.org/v07p3876.htm