%0 Journal Article
%T Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
%A Baohua Qian
%A Changjing Zuo
%A Chuanbin Mao
%A Dandan Zhang
%A Geng Liu
%A Huamao Ye
%A Jiaqi Wang
%A Jingjing Hu
%A Kai Cheng
%A Lei Lu
%A Shanrong Liu
%A Shupeng Liu
%A Xiya Yu
%A Yijun Hu
%A Yongwei Yu
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.18262
%X Understanding the interaction between cancer cells and immunocytes will inspire new cancer therapy strategies. However, how cancer-derived circulating miRNAs modulate such interaction remains unclear. Here we discovered that circulating miR-410-5p, secreted by prostate cancer cells, entered dendritic cells (DCs), with the aid of argonaute-2 protein. The cancer cell antigens stimulated the DCs to produce miR-410-3p, a highly complementary counterpart of miR-410-5p derived from pre-miR-410. The DC-internalized miR-410-5p degraded the miR-410-3p by base pairing and thus inhibited its function in suppressing tumor angiogenesis, promoting tumor growth. Furthermore, blockade of the miR-410-5p upregulated the miR-410-3p to inhibit tumor growth. Our work suggests a new miRNA-mediated role of immunocytes in cancer progression and a new strategy of cancer therapy through suppressing circulating miRNAs.
%K circulating microRNA
%K cancer angiogenesis
%K dendritic cells
%K prostate cancer.
%U http://www.thno.org/v07p1407.htm