%0 Journal Article
%T Arecoline Increases Glycolysis and Modulates pH Regulator Expression in HA22T/VGH Hepatoma Cells, Leading to Increase of Intracellular Ca2+, Reactive Oxygen Species, and Anoikis
%A Bau-Shan Hsieh
%A Hsiao-Ling Cheng
%A Inn-Wen Chong
%A Kee-Lung Chang
%A Li-Wen Huang
%A Tzu-Ching Huang
%A Wen-Tsan Chang
%A Yu-Chen Hu
%J Journal of Cancer
%D 2017
%I Ivyspring International Publisher
%R 10.7150/jca.20523
%X Background: Cancer cells proliferate rapidly and are resistant to cell death, relying on aggravated glycolysis to satisfy their increased demand for energy and biosynthetic precursors. However, this process may create unfavorable microenvironments, such as increased acidity, leading to cytotoxicity. Our previous study demonstrated that arecoline induces anoikis of HA22T/VGH hepatoma cells. The present study aimed to examine if arecoline induced anoikis is related to the glycolytic pathway and explore the underlying mechanisms.
%K Arecoline
%K Glycolysis
%K ROS
%K Calcium ion
%K Anoikis.
%U http://www.jcancer.org/v08p3173.htm