%0 Journal Article
%T MiR-200c Inhibits the Tumor Progression of Glioma via Targeting Moesin
%A Bingjie Liu
%A Chaoshi Niu
%A Chuandong Cheng
%A Dejun Bao
%A Dongxue Li
%A Lei Zhou
%A Lu Deng
%A Suling Liu
%A Wanxiang Niu
%A Weilong Chen
%A Yuanyuan Qin
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.17886
%X We attempt to demonstrate the regulatory role of miR-200c in glioma progression and its mechanisms behind. Here, we show that miR-200c expression was significantly reduced in the glioma tissues compared to paratumor tissues, especially in malignant glioma. Exogenous overexpression of miR-200c inhibited the proliferation and invasion of glioma cells. In addition, the in vivo mouse xenograft model showed that miR-200c inhibited glioma growth and liver metastasis, which is mainly regulated by targeting moesin (MSN). We demonstrated that the expression of MSN in glioma specimens were negatively correlated with miR-200c expression, and MSN overexpression rescued the phenotype about cell proliferation and invasion induced by miR-200c. Moreover, knockdown of MSN was able to mimic the effects induced by miR-200c in glioma cells. These results indicate that miR-200c plays an important role in the regulation of glioma through targeting MSN.
%K glioma
%K miR-200c
%K moesin.
%U http://www.thno.org/v07p1663.htm