%0 Journal Article
%T Complete Disaggregation of MCF-7-derived Breast Tumour Spheroids with Very Low Concentrations of ¦Á-Mangostin Loaded in CD44 Thioaptamer-tagged Nanoparticles
%A Carlo Guarnieri
%A Claudia Pazzini
%A Claudio Muscari
%A Francesca Bonaf¨¨
%A Silvia Marchionni
%J International Journal of Medical Sciences
%D 2019
%R 10.7150/ijms.28135
%X Background: ¦Á-Mangostin (¦ÁMG) is a natural substance that exerts a wide range of antitumor effects. Recently, we described that free ¦ÁMG was able to dissociate multicellular tumour spheroids (MCTSs) generated from breast carcinoma cells and to reduce their cellular viability and motility. Here, ¦ÁMG was encapsulated into lipidic nanoparticles (NPs), conjugated or not to a CD44 thioaptamer, and the anticancer action evaluated against MCF-7 breast MCTSs.
%K ¦Á-mangostin
%K multicellular tumour spheroid
%K breast cancer cell line
%K MCF-7
%K nanoparticle
%K thioaptamer.
%U http://www.medsci.org/v16p0033.htm