%0 Journal Article
%T Al18F-Labeling Of Heat-Sensitive Biomolecules for Positron Emission Tomography Imaging
%A Alfons Verbruggen
%A Catarina Xavier
%A Daniel J Rubins
%A Frederik Cleeren
%A Geert Raes
%A Guy Bormans
%A Joan Lecina
%A Muneer Ahamed
%A Nick Devoogdt
%A Paul McQuade
%A Vicky Caveliers
%A Wenping Li
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.20094
%X Positron emission tomography (PET) using radiolabeled biomolecules is a translational molecular imaging technology that is increasingly used in support of drug development. Current methods for radiolabeling biomolecules with fluorine-18 are laborious and require multistep procedures with moderate labeling yields. The Al18F-labeling strategy involves chelation in aqueous medium of aluminum mono[18F]fluoride ({Al18F}2+) by a suitable chelator conjugated to a biomolecule. However, the need for elevated temperatures (100-120 ˇăC) required for the chelation reaction limits its widespread use. Therefore, we designed a new restrained complexing agent (RESCA) for application of the AlF strategy at room temperature.
%K Al18F-labeling
%K PET
%K human serum albumin
%K nanobody
%K affibody.
%U http://www.thno.org/v07p2924.htm