%0 Journal Article
%T GRO-¦Á and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NF¦ÊB signaling cascade
%A Dakang Xu
%A David Wai Chan
%A Hermit Wai-Man Tang
%A Hextan Yuen-Sheung Ngan
%A Huijuan Yang
%A Karen Kar-Loen Chan
%A Mingo Ming-Ho Yung
%A Patty Chun-Hui Cai
%A Siew-Fei Ngu
%A Thomas Ho-Yin Leung
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22536
%X Intraperitoneal metastasis is a common occurrence and is usually involved in the poor prognosis of ovarian cancer. Its specific metastatic pattern implies that certain indispensable microenvironmental factors secreted in the peritoneal cavity can direct metastatic ovarian cancer cells to permissive niches for secondary lesion formation. However, the underlying molecular mechanisms are ill defined. Herein, we report that GRO-¦Á and IL-8 are predominately upregulated in culture media derived from either normal or cancerous omenta and are associated with increased ovarian cancer aggressiveness.
%K chemokines
%K IL-8
%K GRO-¦Á
%K CXCR2
%K NF¦ÊB signaling
%K ovarian cancer
%U http://www.thno.org/v08p1270.htm