%0 Journal Article
%T Systematic Assessment of Strategies for Lung-targeted Delivery of MicroRNA Mimics
%A Duncan J. Stewart
%A Kenny Schlosser
%A Mohamad Taha
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22912
%X There is considerable interest in the use of synthetic miRNA mimics (or inhibitors) as potential therapeutic agents in pulmonary vascular disease; however, the optimal delivery method to achieve high efficiency, selective lung targeting has not been determined. Here, we sought to investigate the relative merits of different lung-targeted strategies for delivering miRNA mimics in rats.
%K microRNA
%K pulmonary hypertension
%K delivery
%K mimic
%K transfection
%K in vivo
%K rats
%K intratracheal
%K intranasal
%K intravenous
%K subcutaneous
%K intraperitoneal
%U http://www.thno.org/v08p1213.htm