%0 Journal Article
%T Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke
%A Celestine Santosh
%A David Brennan
%A Graeme A Deuchar
%A I Mhairi Macrae
%A Martin Shaw
%A William M Holmes
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.21685
%X The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two complementary novel MRI techniques (Glasgow Oxygen Level Dependant (GOLD) Metabolic Imaging), which when combined with a perfluorocarbon (PFC) based oxygen carrier and hyperoxia can identify penumbra due to dynamic changes related to continued metabolism within this tissue compartment. Our aims were (i) to investigate whether PFC offers similar enhancement of the second technique (Lactate Change) as previously demonstrated for the T2*OC technique (ii) to demonstrate both GOLD metabolic imaging techniques working concurrently to identify penumbra, following administration of Oxycyte£¿ (O-PFC) with hyperoxia.
%K Acute Ischaemic Stroke
%K perfluorocarbon
%K penumbra
%K GOLD metabolic imaging
%K MRI
%U http://www.thno.org/v08p1706.htm