%0 Journal Article
%T Porphyrin-grafted Lipid Microbubbles for the Enhanced Efficacy of Photodynamic Therapy in Prostate Cancer through Ultrasound-controlled In Situ Accumulation
%A Chen Qiu
%A Chuang Gao
%A Enze Qu
%A Min Chen
%A Rongqin Zheng
%A Tinghui Yin
%A Xiaolong Liang
%A Xiaoyou Wang
%A Yongjiang Mao
%A Yujia You
%A Zhifei Dai
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22469
%X Photodynamic therapy (PDT) holds promise for focal therapy of prostate cancer (PCa). However, the therapeutic efficacy needs improvement, and further development of PDT for PCa has challenges, including uncertainty of photosensitizers (PSs) accumulation at the tumor site and difficulty in visualizing lesions using conventional ultrasound (US) imaging. We have developed novel porphyrin-grafted lipid (PGL) microbubbles (MBs; PGL-MBs) and propose a strategy to integrate PGL-MBs with US imaging to address these limitations and enhance PDT efficacy.
%K porphyrin-grafted lipid
%K microbubbles
%K photosensitizer
%K ultrasound-targeted microbubble destruction
%K photodynamic therapy
%U http://www.thno.org/v08p1665.htm