%0 Journal Article
%T Blocking CDK1/PDK1/¦Â-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma
%A Albert Chi Yan Chan
%A Chuan Xing Wu
%A Ka Wing Ma
%A Kwan Man
%A Simon Hing Yin Tsang
%A Siu Ho Chok
%A Tan To Cheung
%A Wei Xia
%A Xiao Qi Wang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25487
%X Rationale: Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein CDK1/PDK1/¦Â-Catenin is activated, suggesting that inhibition of this pathway may have therapeutic potential.
%K cancer stem cells
%K hepatocellular carcinoma
%K PDX models
%K CDK1 inhibitor
%K RO3306
%K sorafenib
%U http://www.thno.org/v08p3737.htm