%0 Journal Article
%T Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression
%A Bo Zhu
%A Chengchao Xu
%A Dianhua Chen
%A Jianfei Sheng
%A Jie Wang
%A Jigang Wang
%A Pingping Shen
%A Qilai Huang
%A Qingsong Lin
%A Renxiang Tan
%A Wei Li
%A Xiao Chen
%A Yew Mun Lee
%A Yin Kwan Wong
%A Yong Zou
%A Zichun Hua
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24336
%X Many plant-specialized metabolites have remedial properties and provide an endless chemical resource for drug discovery. However, most of these metabolites have promiscuous binding targets in mammalian cells and elicit a series of responses that collectively change the physiology of the cells. To explore the potential of these multi-functional and multi-targeted drugs, it is critical to understand the direct relationships between their key chemical features, the corresponding binding targets and the relevant biological effects, which is a prerequisite for future drug modification and optimization.
%K CPAT
%K resveratrol
%K target identification
%K chemical proteomics
%K cancer metastasis.
%U http://www.thno.org/v08p3504.htm