%0 Journal Article
%T Programmed Death Ligand 1 (PD-L1) Expression in Primary Angiosarcoma
%A Annarosaria De Chiara
%A Antonio Pizzolorusso
%A Gerardo Botti
%A Giosu¨¨ Scognamiglio
%A Laura Marra
%A Maurizio Di Bonito
%A Monica Cantile
%A Rossella De Cecio
%J Journal of Cancer
%D 2017
%I Ivyspring International Publisher
%R 10.7150/jca.19060
%X Angiosarcomas are rare malignant endothelial-cell tumors of vascular or lymphatic origin, and are among the most aggressive subtypes of soft-tissue sarcomas. The prognosis is poor and treatment is challenging in many cases. PD-1/PD-L1 pathway plays a critical role in immune escape of tumor cells. Recent studies described that PD-L1 is widely expressed in various types of cancer, providing the basis for the development of PD1/PD-L1 antibodies as anti-cancer immunotherapy. Despite the well-known potential of PD-L1 as prognostic and predictive biomarker, only few studies described its IHC expression in cancer subtypes for the extreme difficulty in developing standard protocol with the different antibody clones available.
%K angiosarcoma
%K PD-L1
%K IHC evaluation.
%U http://www.jcancer.org/v08p3166.htm