%0 Journal Article
%T A Programmed Nanoparticle with Self-Adapting for Accurate Cancer Cell Eradication and Therapeutic Self-Reporting
%A Bo-Yang Yu
%A Huangxian Ju
%A Jiangwei Tian
%A Liwei Huang
%A Siyao Hu
%A Xianfei Zhuang
%A Ye Yang
%A Yingping Luo
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.18187
%X To achieve the best therapeutic efficacy and good prognosis, the drugs necessitate tailored profiles of excellent spatiotemporal control and therapeutic monitoring. Here we introduce a programmed theranostic nanoparticle with self-adapting properties for tumor-specific systemic treatment, including stealthy surface to prolong circulation time in blood, surface charge-reversion for tumor targeting, receptor-mediated internalization to increase intracellular accumulation, ˇ°proton sponge effectˇ± for controllable drug release and escape from endo/lysosome. Encouragingly, in the process of drug-induced apoptosis, the therapeutic efficacy can be reported by fluorescence imaging in vivo, in situ and in real time. Therefore, this work provides a new paradigm for design of programmed theranositc nanomedicine and offers promising prospects for precise tumor treatment.
%K cancer
%K programmed nanoparticle
%K drug release
%K self-adapting
%K therapeutic self-reporting
%U http://www.thno.org/v07p1245.htm