%0 Journal Article %T Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling %A Chang-Xian LI %A Chung-Mau LO %A Irene Oi Lin NG %A Jun YU %A Kevin Tak-Pan NG %A Kwan MAN %A Qiao CHENG %A Sookja K CHUNG %A Xiao-Bing LIU %A Yan SHAO %J Theranostics %D 2017 %I Ivyspring International Publisher %R 10.7150/thno.20085 %X Background and Aims: Expanded donor criteria poses increased risk for late phase complications such as fibrosis that lead to graft dysfunction in liver transplantation. There remains a need to elucidate the precise mechanisms of post-transplant liver damage in order to improve the long-term outcomes of marginal liver grafts. In this study, we aimed to examine the role of oval cells in fibrogenic development of marginal liver grafts and explore the underlying mechanisms. %K hepatic bipotent cells %K small-for-size fatty graft injury %K aldose reductase %K notch signaling. %U http://www.thno.org/v07p4879.htm