%0 Journal Article
%T Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling
%A Chang-Xian LI
%A Chung-Mau LO
%A Irene Oi Lin NG
%A Jun YU
%A Kevin Tak-Pan NG
%A Kwan MAN
%A Qiao CHENG
%A Sookja K CHUNG
%A Xiao-Bing LIU
%A Yan SHAO
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.20085
%X Background and Aims: Expanded donor criteria poses increased risk for late phase complications such as fibrosis that lead to graft dysfunction in liver transplantation. There remains a need to elucidate the precise mechanisms of post-transplant liver damage in order to improve the long-term outcomes of marginal liver grafts. In this study, we aimed to examine the role of oval cells in fibrogenic development of marginal liver grafts and explore the underlying mechanisms.
%K hepatic bipotent cells
%K small-for-size fatty graft injury
%K aldose reductase
%K notch signaling.
%U http://www.thno.org/v07p4879.htm