%0 Journal Article
%T Interleukin-6 Mediates Post-Infarct Repair by Cardiac Explant-Derived Stem Cells
%A Alex Nantsios
%A Audrey E Mayfield
%A Bin Ye
%A Darryl R Davis
%A Duncan J Stewart
%A Pushpinder Kanda
%A Richard Seymour
%A Sandrine Parent
%A Seth Mount
%A Somya Dixit
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.19435
%X Although patient-sourced cardiac explant-derived stem cells (EDCs) provide an exogenous source of new cardiomyocytes post-myocardial infarction, poor long-term engraftment indicates that the benefits seen in clinical trials are likely paracrine-mediated. Of the numerous cytokines produced by EDCs, interleukin-6 (IL-6) is the most abundant; however, its role in cardiac repair is uncertain. In this study, a custom short-hairpin oligonucleotide lentivirus was used to knockdown IL-6 in human EDCs, revealing an unexpected pro-healing role for the cytokine.
%K Cell therapy
%K interleukin-6
%K stem cells
%K myocardial infarction
%U http://www.thno.org/v07p4850.htm