%0 Journal Article
%T Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins
%A Adva Krivitsky
%A Anat Eldar-Boock
%A Anna Scomparin
%A Dikla Ben-Shushan
%A Doron Shabat
%A Eilam Yeini
%A Emmanuelle Merquiol
%A Evgeni Pisarevsky
%A Galia Blum
%A Galia Tiram
%A Hadas Gibori
%A Hila Doron
%A Neta Erez
%A Ori Green
%A Rachel Blau
%A Rachel Grossman
%A Ronit Satchi-Fainaro
%A Sahar Israeli Dangoor
%A Yael Ben-Nun
%A Yana Epshtein
%A Zvi Ram
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.23853
%X Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that there are no residual cancer cells left behind. Residual cells at the incision margin of the tissue removed during surgery are associated with tumor recurrence and poor prognosis for the patient. In order to remove the tumor tissue completely with minimal collateral damage to healthy tissue, there is a need for diagnostic tools that will differentiate between the tumor and its normal surroundings.
%K precision nanomedicine
%K polymers
%K PGA
%K HPMA copolymer
%K theranostics
%K molecular imaging
%K NIR fluorescence
%K image-guided surgery
%U http://www.thno.org/v08p3437.htm