%0 Journal Article
%T Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice
%A Ben Wu
%A Chun-Yuan Chen
%A Hao Yin
%A Hui Xie
%A Jia Cao
%A Jie Huang
%A Juan Luo
%A Ping-Li Xie
%A Shan-Shan Rao
%A Shu-Ying Liu
%A Tai Rao
%A Tuan-Hui Chen
%A Xiong-Ke Hu
%A Xu Cao
%A Yan Zhang
%A Yi-Juan Tan
%A Yin Hu
%A Zhen-Xing Wang
%A Zheng-Zhao Liu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22144
%X Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate type H vessel formation and thereby to promote osteogenesis. This study aimed to explore whether harmine, a ¦Â-carboline alkaloid, is capable of preventing bone loss in OVX mice by promoting preosteoclast PDGF-BB-induced type H vessel formation.
%K harmine
%K preosteoclast
%K PDGF-BB
%K angiogenesis
%K osteogenesis
%U http://www.thno.org/v08p2435.htm