%0 Journal Article %T Mutational Landscape of cfDNA Identifies Distinct Molecular Features Associated With Therapeutic Response to First-Line Platinum-Based Doublet Chemotherapy in Patients with Advanced NSCLC %A Bo Du %A Caicun Zhou %A Chao Zhao %A Chunxia Su %A Fei Zhou %A Fengying Wu %A Fred R. Hirsch %A Guanghui Gao %A Henghui Zhang %A Hui Yu %A Jianfei Wang %A Jiayu Li %A Jing Zhao %A Jun Zhang %A Shengxiang Ren %A Tao Jiang %A Wei Li %A Weijing Cai %A Wenbo Han %A Xiaoxia Chen %A Xuefei Li %J Theranostics %D 2017 %I Ivyspring International Publisher %R 10.7150/thno.21687 %X Rationale To investigate whether the mutational landscape of circulating cell-free DNA (cfDNA) could predict and dynamically monitor the response to first-line platinum-based chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). %K Non-small-cell lung cancer %K circulating cell-free DNA %K chemotherapy %K molecular mutational burden %U http://www.thno.org/v07p4753.htm