%0 Journal Article
%T Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment
%A Andrew Tutt
%A Christina Wefers
%A Dominic Patel
%A Fabian Flores-Borja
%A Hanna Milewicz
%A Hannah Smith
%A Jae Jin Lee
%A Johannes Roth
%A Manuel Rodriguez-Justo
%A Margaret S Cooper
%A Michel Eisenblaetter
%A Philip J Blower
%A Rebekka Hueting
%A Thomas Vogl
%A Tobias Schaeffter
%A Tony Ng
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.17138
%X Background Systemic cancer spread is preceded by the establishment of a permissive microenvironment in the target tissue of metastasis - the premetastatic niche. As crucial players in establishment of the pre-metastatic niche, myeloid derived suppressor cells (MDSC) release S100A8/A9, an exosomal protein that contributes to metastasis, angiogenesis, and immune suppression. We report the application of antibody-based single-photon emission computed tomography (SPECT) for detection of S100A8/A9 in vivo as an imaging marker for pre-metastatic tissue priming.
%K Premetastatic niche
%K tumour immunology
%K imaging
%K MDSC.
%U http://www.thno.org/v07p2392.htm