%0 Journal Article
%T Targeting ALDH2 for Therapeutic Interventions in Chronic Pain-Related Myocardial Ischemic Susceptibility
%A Chen Li
%A Chunhu Gu
%A Heng Ma
%A Jingrun Yang
%A Lu Yu
%A Nanhu Quan
%A Wanqing Sun
%A Zhaoling Shi
%A Zheng Yang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22414
%X Clinical observations have demonstrated a link between chronic pain and increased ischemic heart disease mortality, but the mechanisms remain elusive. Reactive aldehydes have recently been confirmed as a new player in pain pathologies, while our previous study demonstrated that reactive aldehydes (4-HNE) induced carbonyl stress contributing to myocardial ischemic intolerance. The aim of this study was to explore whether chronic pain increases susceptibility to myocardial ischemia/reperfusion (MI/R) injury and to investigate the underlying mechanisms focusing on toxic aldehyde and carbonyl stress.
%K chronic pain
%K myocardial ischemic intolerance
%K ALDH2
%K 4-HNE
%K carbonylation.
%U http://www.thno.org/v08p1027.htm