%0 Journal Article
%T Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
%A Anna Orlova
%A Bogdan Mitran
%A Elin Lindstr£¿m
%A Filippa Fleetwood
%A Francis P. Roche
%A John L£¿fblom
%A Lena Claesson-Welsh
%A Ram Kumar Selvaraju
%A Rezan G¨¹ler
%A Sara S. Rinne
%A Stefan St£¿hl
%A Vladimir Tolmachev
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24395
%X Vascular endothelial growth factor receptor-2 (VEGFR2) is a key mediator of angiogenesis and therefore a promising therapeutic target in malignancies including glioblastoma multiforme (GBM). Molecular imaging of VEGFR2 expression may enable patient stratification for antiangiogenic therapy. The goal of the current study was to evaluate the capacity of the novel anti-VEGFR2 biparatopic affibody conjugate (ZVEGFR2-Bp2) for in vivo visualization of VEGFR2 expression in GBM.
%K VEGFR2
%K affibody molecule
%K molecular imaging
%K SPECT
%K orthotopic glioma model
%K in vivo
%U http://www.thno.org/v08p4462.htm