%0 Journal Article
%T CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death
%A Alejandra Pera
%A Bernhard Reus
%A Chakravarthi Rajkumar
%A Fabio Albanese
%A Florian Kern
%A George Morrow
%A Helen E Smith
%A James R Msonda
%A Kevin A Davies
%A Michael Hallensleben
%A Murielle Verboom
%A Nadia Terrazzini
%A Pinar Blowers
%A Rainer Blasczyk
%A Stefano Caserta
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.27428
%X An increased risk of cardiovascular death in Cytomegalovirus (CMV)-infected individuals remains unexplained, although it might partly result from the fact that CMV infection is closely associated with the accumulation of CD28null T-cells, in particular CD28null CD4 T-cells. These cells can directly damage endothelium and precipitate cardiovascular events. However, the current paradigm holds that the accumulation of CD28null T-cells is a normal consequence of aging, whereas the link between these T-cell populations and CMV infection is explained by the increased prevalence of this infection in older people. Resolving whether CMV infection or aging triggers CD28null T-cell expansions is of critical importance because, unlike aging, CMV infection can be treated.
%K CD28null CD4 T-cells
%K CD28null CD8 T-cells
%K cardiovascular disease
%K aging
%K Cytomegalovirus
%K coronary complications
%U http://www.thno.org/v08p4509.htm