%0 Journal Article
%T Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis
%A Anders Larsson
%A Andreas Tolf
%A Henrik Zetterberg
%A Joachim Burman
%A Julia Steinmetz
%A Kim Kultima
%A Ola Spjuth
%A Payam Emami Khoonsari
%A Per-Johan Jakobsson
%A Stephanie Herman
%A Torbj£¿rn £¿kerfeldt
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26249
%X Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originating from multiple sources with the aim of discovering a condensed set of biomarkers that in combination could distinguish the progressive degenerative phenotype of multiple sclerosis (SPMS) from the relapsing-remitting phenotype (RRMS).
%K data integration
%K multiple sclerosis
%K disease progression
%K metabolomics
%K biomarker
%U http://www.thno.org/v08p4477.htm