%0 Journal Article
%T Jujuboside A promotes A¦Â clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPAR¦Ã pathway
%A Cheng Qian
%A Fei Qian
%A Hua Yang
%A Hui-Jun Li
%A Lifan Tu
%A Mu Zhang
%A Ping Li
%A Pyone Myat Thu
%A Qingling Liu
%A Xiaojun Xu
%A Xin Zhang
%A Yanyan Wang
%A Yaping Zhou
%A Zu-Guo Zheng
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26164
%X Rationale: It has been reported that peroxisome proliferator activated receptor ¦Ã (PPAR¦Ã) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while the mechanism is unclear. This study aims to unravel the mechanism that amyloid ¦Â (A¦Â) decreases PPAR¦Ã and attempted to discover lead compound that preserves PPAR¦Ã.
%K Alzheimer's disease
%K amyloid ¦Â
%K Jujuboside A
%K PPAR¦Ã
%K HSP90¦Â
%K Axl
%U http://www.thno.org/v08p4262.htm