%0 Journal Article
%T Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1¦Á in lung cancer
%A Ann M. Bode
%A Feng Shi
%A Gao Qiang
%A Jia Fan
%A Jian Zhou
%A Jiangjiang Li
%A Jingchen Lu
%A Liling Li
%A Longlong Xie
%A Min Tang
%A Namei Li
%A ShuangJian Qiu
%A Shuo You
%A Wei Yi
%A Weizhong Wu
%A Xiangjian Luo
%A Xiaolan Liu
%A Xin Song
%A Xinxian Weng
%A Ya Cao
%A Ya He
%A Yueshuo Li
%A Zheqiong Tan
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.21524
%X Hotspot mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) have been studied in several cancers. However, the function of wild-type IDH2 in lung cancer and the mechanism of its contribution to growth of cancer cells remain unknown. Here, we explored the role and mechanism of wild-type IDH2 in promoting growth of lung cancer.
%K isocitrate dehydrogenase 2
%K lung cancer
%K Warburg effect
%K tumor growth
%K HIF1-¦Á
%U http://www.thno.org/v08p4050.htm