%0 Journal Article
%T Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression
%A Guoqun Wang
%A Jiaojiao zhao
%A Shuli Zhao
%A Yaxian Xue
%A Yayi Hou
%A Yuan Cheng
%A Yuchen Pan
%A Zhengkui Zhang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.29746
%X Macrophages orchestrate inflammation and control the promotion or inhibition of tumors and metastasis. Ferumoxytol (FMT), a clinically approved iron oxide nanoparticle, possesses anti-tumor therapeutic potential by inducing pro-inflammatory macrophage polarization. Toll-like receptor 3 (TLR3) activation also potently enhances the anti-tumor response of immune cells. Herein, the anti-tumor potential of macrophages harnessed by FMT combined with the TLR3 agonist, poly (I:C) (PIC), and FP-NPs (nanoparticles composed of amino-modified FMT (FMT-NH2) surface functionalized with PIC) was explored.
%K C)
%K FP-NPs
%K melanoma
%U http://www.thno.org/v08p6307.htm