%0 Journal Article
%T CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism
%A Chen Liu
%A Dan Li
%A Dwayne G. Stupack
%A Huan Qiao
%A Jing Xun
%A Juan Wang
%A Jun Li
%A Na Luo
%A Ruifang Gao
%A Wei Zhou
%A Wenzhi Shen
%A Xiru Li
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.28721
%X CD44 is a single-pass cell surface glycoprotein that is distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression. In this regard, the CD44high cell population demonstrates not only the ability to regenerate a heterogeneous tumor, but also the ability to self-regenerate when transplanted into immune-deficient mice. However, the exact role of CD44 in cancer stem cells remains unclear in part because CD44 exists in various isoforms due to alternative splicing.
%K PFKFB4
%K CD44ICD
%K stemness
%K glucose metabolism
%U http://www.thno.org/v08p6248.htm