%0 Journal Article
%T Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden
%A Hongen Liao
%A Jie Tang
%A Liwei Zhang
%A Wei Chang
%A Xinran Zhang
%A Yingwei Fan
%A Yu Sun
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25357
%X Brain tumor delineation and treatment are the main concerns of neurosurgeons in neurosurgical operations. Bridging the gap between imaging/diagnosis and treatment will provide great convenience for neurosurgeons. Here, we developed an optical theranostics platform that helps to delineate the boundary and quantitatively analyze glioblastoma multiforms (GBMs) with bioluminescence imaging (BLI) to guide laser ablation, and we imaged the GBM cells with two-photon microscopy (TPM) to visualize the laser ablation zone in vivo.
%K minimally invasive optical theranostics
%K laser ablation
%K bioluminescence imaging
%K two-photon microscopy
%K GBM resection
%K multimodality guided surgery
%U http://www.thno.org/v08p4072.htm