%0 Journal Article
%T P-glycoprotein-targeted photodynamic therapy boosts cancer nanomedicine by priming tumor microenvironment
%A Chengqiong Mao
%A Fang Li
%A Waldemar Debinski
%A Xin Ming
%A Yan Zhao
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.29580
%X Cancer nanomedicines only modestly improve the overall survival of patients because their anticancer activity is limited by biological barriers posed by the tumor microenvironment. Currently, all the drugs in FDA-approved cancer nanomedicines are substrates for P-glycoprotein (Pgp), and thus, Pgp-mediated multidrug resistance (MDR) remains a hurdle for cancer nanomedicines.
%K antibody conjugates
%K cancer multidrug resistance
%K cancer nanomedicine
%K cancer targeted therapy
%K P-glycoprotein
%K photodynamic therapy.
%U http://www.thno.org/v08p6274.htm