%0 Journal Article
%T Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology
%A Klaus Fassbender
%A Yang Liu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.30953
%X Microglial inflammatory activation contributes to chronic cerebral hypoperfusion-induced brain pathology. This editorial highlights a study by Qin et al. (Theranostics 2018; 8(19):5434-5451. doi:10.7150/thno.27882) that deficiency of TLR4 attenuates cognitive dysfunction and white matter injury by reducing autophagy and pro-inflammatory activation in microglia.
%K chronic cerebral hypoperfusion
%K microglia
%K inflammation
%K autophagy
%K TLR4.
%U http://www.thno.org/v08p6355.htm