%0 Journal Article
%T Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin
%A Chun-Tao Che
%A Hui Tian
%A Jian-Dong Jiang
%A Jie Fu
%A Jin-Bo Yu
%A Li-Bin Pan
%A Lin Cong
%A Ran Peng
%A Shu-Rong Ma
%A Yan Wang
%A Zhen-Xiong Zhao
%A Zuo-Guang Zhang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.28068
%X The gut microbiota is increasingly recognized to influence brain function through the gut-brain axis. Albiflorin, an antidepressant natural drug in China with a good safety profile, is difficult to absorb and cannot be detected in the brain after oral administration. Accordingly, the antidepressant mechanism of albiflorin in vivo has not been elucidated clearly.
%K gut-brain axis
%K albiflorin
%K gut microbiota
%K depression
%K benzoic acid
%K carboxylesterase
%U http://www.thno.org/v08p5945.htm