%0 Journal Article
%T CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy
%A Cui Tian
%A Hong-Xia Wang
%A Hui-Hua Li
%A Jia-Wei Liao
%A Qiu-Yue Lin
%A Song Lai
%A Xin Xie
%A Yun-Peng Xie
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.27706
%X Rationale: Sustained cardiac hypertrophy often leads to heart failure (HF). Understanding the regulation of cardiomyocyte growth is crucial for the treatment of adverse ventricular remodeling and HF. Cell division cycle 20 (CDC20) is an anaphase-promoting complex activator that is essential for cell division and tumorigenesis, but the role of CDC20 in cardiac hypertrophy is unknown. We aimed to test whether CDC20 participates in the regulation of pathological cardiac hypertrophy and investigate the underlying mechanism in vitro and in vivo.
%K CDC20
%K transverse aortic constriction
%K cardiac hypertrophy
%K LC3
%K ROS
%U http://www.thno.org/v08p5995.htm